Showing posts with label Scoline. Show all posts
Showing posts with label Scoline. Show all posts

Tuesday, March 24, 2009

Premedication schedule never works due to many variables

Premedication in private practice does not work except with the first case in the morning when anaesthetist and surgeon work at the same nursing home. The scheduled time is disturbed due to:

  • Transport difficulties
  • Either the surgeon or anaesthetist delayed in the previous case
  • Patients relatiives not present
  • Patient sent for special exam for ureteric stone or some X-ray investigation needed
  • Delay by the theatre staff, equipment


Hence one can depend on premedication on the 1st case only. The rest of the schedule has to be conducted with IV premedication + inductions. Injection Atropine, which was prescribed ½ hour before, does not help in modern practice. It was a must for open drop ether anaesthesia where suppression of salivary secretion was essential. Injection atropine of dryness and some may even start thinking that some extraordinary complications is taking place due to drying and rapid action of the heart and feverish sensation. The olden days premedication for stealing the thyroid in thyrotoxicosis do not apply as they are never taken on table unless sympathetic activity is totally suppressed with anti thyroid drugs.
With IV medication one is assured of
Full administration of drug in system (leaky syringes used by nurses)
Only one injection prick patient feels. This is important in children, as they are very uncooperative for the 2nd injection.
Premedication for infants either by oral or by injection has to be given by ½ hours before induction is by inhalation method. Delayed action like I.V. atropine may not act immediately and appearance of secretion due to endotracheal tube narrow the air passages by secretions.
For patients who are anxious a 10 mg. Diazepam at night or even a tab of diazepam early morning will alleviate the problem.
In patients where induction dose of Thiopentone is likely to be dangerous heavy premedications or basal narcosis is a must, like mitral stenosis patients. Avoid atropine for tachycardia it produces. In very sick and poor risk patients it is better to avoid any premedication.
In some public hospitals the order of patients to be taken for surgery is not known and hence the ward sister gives the injection atropine to all patients at 7.30am as patients are scheduled for surgery at 8.00am (which normally does not start till 8.30 or 9.00 am). The system is followed for years together as anaesthetist insist on atropine ½ hour before. They do not mind delaying the induction till ½ hour is over after injection of atropine is given. I do not understand the rationale behind this plan. Is it because you do conduct less cases in the day and leave early for home? Or is it to show your domination? Nobody is bothered about the suffering of the patient.
Vagolytic action of atropine in pharmacologic doses to prevent vagal arrest is doubted and hence insistence of giving it ½ hour before surgery is sheer ignorance, as IV atropine acts immediately it can certainly replace IM as drying effect is not necessary for IV induction and intubation. If it is given that the 1st drug to be followed by Thiopentone or even mixed with thiopentone (sometimes produces precipitate which dissolves) also acts before scoline and prevents the Cholinergic effect of scoline.
In one infant for congenital cataract the surgeon had prescribed atropine drops in the eye. He did not order oral or sub cut atropine. On arrival we found that atropine drops had produced complete systemic effect with facial flushing tachycardia and dry mouth. Induction with open drop could be take up immediately without injection atropine
Premedication Schedule – never works in private practice except the first case. As you are likely to be delayed, surgeon’s arrival, preparation of OT due to previous operation.

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Saturday, May 24, 2008

Use new drugs with caution

Beware of new drugs being introduced in the market...The pharmacologist and the drug industry have to criticize the old drugs to replace them with new. They have criticized Thiopentone to make way for their costly drug-Propofol. They highlight the rapid recovery of consciousness, which can be advantageously used for operations for day care surgery. But one has to remember that its use as induction agent for a prolonged surgery has no meaning. Even Thiopentone is metabolised and excreted in that time. The cost of the new drug is very high. The solvent of the drug is Egg white and soya bean oil. One raises a doubt to inject a foreign protein I.V. that may land you with serious anaphylactoid reaction and death. Thus you have to weigh the advantages and disadvantages by discussing with your colleagues and not be misled by the medical representatives.
They are now trying to throw out Scoline by propagating single long acting muscle relaxant with increased initial dose to be used for intubation. They try to highlight the bad effects of Succinylcholine Chloride. But ask yourself a simple question “How many deaths have you heard or seen in clinical practice under Scoline.” Except in cases where the drug is definitely contra indicated with raised serum potassium due to any cause at least in my practice I have not come across a single case with death due to Scoline. The first successful drug Atracurium which was successfully launched to replace Scoline was found later to cause anaphylactoid reaction due to intubating dose. It was abandoned in Europe and was being dumped in India. Luckily better drugs appeared in the market and we in India were prevented from being guinea pigs.

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#21-25: Private Practice Anesthesia- Do’s and Dont’s


  1. Beware of precipitous fall of BP in cases with induction of GA with regular dose of Thiopentone in failed spinal or epidural.
  2. Patients with diabetes convert them on soluble insulin. If not possible give 10 units/ 500 dextrose. If the diabetes is mild and controlled on tablets give 10 units/ alt bottle of dextrose (5%); do not over treat. It is better to have a slightly hyperglycaemic patient rather than hypoglycaemic under anaesthesia. The only sign of caution you get is severe unexplainable tachycardia. Beware of armchair physicians who have not studied patients under anaesthesia or even entered the operation theatre.
  3. Hypertensive patients who are controlled on drugs typically continue the drugs even before operation. If the BP is high, mainly due to fear in most cataract patients, administer 5-10 mg Nifedipine under the tongue on operation table before you start.
  4. High risk patients, toxaemic, gasping with electrolyte imbalance: In this case, your first duty is to keep the patient alive. Avoid Thiopentone or if you do use it for your satisfaction administer homeopathic doses. Forget about Scoline twitchings and awareness of intubation. If Boyle’s Apparatus is available, do nitrous oxide, oxygen induction till eyelash reflex disappears. Give full dose (100 mg) of Scoline, do not compromise. Fractionate the muscle relaxant dose (long acting) or avoid if you can manage with repeated dilute Scoline. The dose needed may be unimaginably small.
  5. Plan your method of anaesthesia well. Do not give spinal if the operation is not likely finish in time. Do not give Thiopentone only for surgeries causing immense pain. Use a combination of drugs with analgesic and amnesic drug.

#26-30: Private Practice Anesthesia- Do’s and Dont’s

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#16-20: Private Practice Anesthesia- Do’s and Dont’s


  1. Never be in a hurry to send the patient back to the ward if the procedure was done under a muscle relaxant. If in doubt try IPPR; if permitted the patient needs reintubation or IPPR with mask till he is completely reversed.
  2. Rising BP; not the colour or consciousness, indicate inadequate reversal. Transfer only if the BP is steady and the patient is conscious.
  3. All patients who have received muscle relaxant (long acting) must be reversed with at least 0.5 to 1 mg. Prostigmin for even a small dose of muscle relaxant.
  4. Patients having long acting spinal anaesthetic drugs must be under observation with written instructions for maintenance of BP in post-operative period.
  5. In patients with known full stomach or even expected full stomach induce with head up tilt, remove the Ryle’s tube after proper suction in different positions. Oxygenate with 100% oxygen. Do not ventilate after Scoline. Ask the surgeon to give tracheal pressure, introduce the laryngoscope blade only when the patient is fully relaxed and intubate. Study your position for intubation (take a flat stool to stand on if necessary) with head up tilt.

#21-25: Private Practice Anesthesia- Do’s and Dont’s

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